The aim of this work was to prepare a bi-layered core tablet of salbutamol sulfate coated with locust bean gum polymer for use as a chronotherapeutic drug delivery system to treat nocturnal asthma at- tacks. Salbutamol sulfate is intended to be delivered via a pH- and time -dependent chronotherapeutic drug delivery system, and the purpose of this study is to examine how the locust bean gum polymer coating af- fects drug release from hydroxypropyl methylcellulose matrix. Asthma incidence is highest in the early morning, when it is known as the "morning dip." The disease could be efficiently controlled by a formula- tion that could deliver the medicine at the proper concentration imme- diately before the attack. Maintaining the medication release after that point would allow the dosage to be administered once daily. The medi- cation was given as two tablets that were directly compressed together. Salbutamol (4 mg for sustained release and 2 mg for burst release) were present in the core pill. To achieve a time lag of 5 hours for the initial burst release, the core was compression coated with a swellable polymer HPMC and then dip coated with polymer locust bean gum in a 1:1 ratio, a pH independent semipermeable membrane. After five hours, the designed system effectively discharged the first dose, which was then maintained for over twelve hours. For the most part, the drug re- lease afterwards 0 order kinetics. With this dosage, the nighttime asth- ma would be effectively controlled.

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ONLINE ISSN:2456-8244

Keywords: Chronotherapy Salbutamol HPMC Locust bean gum Nocturnal Asthma

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