In the present study niosomes of ciprofloxacin were developed by thin film hydration technique and incorporated into gel formula- tion suitable for topical application. The niosomes prepared using var- ying ratio of surfactant (span 20 and tween 20) and cholesterol were evaluated for entrapment efficiency and in vitro release. From the re- sults of the release studies it was found that the maximum amount of drug was released from formulations F2 (79.74 %) and F5 (71.68 %) over a period of 12 h at an almost steady rate. The higher amount of drug release along with the higher entrapment efficiency make the formulations F2 and F5 containing surfactant to cholesterol ratio of 1:2 the most promising formulations. The gel loaded with niosomal formulations F2 and F5 were prepared using Carbopol 934 as the gel- ling agent and propylene glycol as the plasticizer. The drug content in all the formulations ranged from 96.4 to 99.1 % confirming the incor- poration of the niosomes into the gel base. The in-vitro drug diffusion study of ciprofloxacin niosomal gel was done using dialysis membrane in Franz diffusion cell using phosphate buffered saline (PBS) pH 7.4 enriched with 10% v/v of methanol as the diffusion medium. The for- mulations NG1 (80.22 %) and NG3 (72.68 %) containing 1% Carbopol 934 were found to release significant amount of drug from the gel over a period of 12 h as compared to the formulations with 2% carbopol.

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ONLINE ISSN:2456-8244

Keywords: Niosome, gel, carbopol, bioavailability, ciprofloxacin

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