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JOURNAL OF PHARMACOLOGY AND BIOMEDICINE
ISSN.2456-8244
Editor-in-Chief
Dr.Richa Mishra Online ISSN
2456-8244 Publisher
RB-Science Abbreviation
J. Pharmacol. Biomed
ABSTRACT

Drug loaded liposomes were prepared by a reverse phase evaporation method using phospholipid (Soy lecithin), cholesterol and stearylamine for having stable particles. The characterization of the liposomes was carried out by estima- tion of Azithromycin, estimation of encapsulation efficiency, in vitro drug release, particles size, and stability of the lipo- somes. The antibacterial action of the liposome solution was assessed by disc diffusion method. The particle size of the formulations ranged from 3.12 ± 5.429 to 3.60 ± 6.519 µm and the entrapment efficiency ranged from 42.17 to 67.33 %. All the formulations released 62 to 75% drug at the end of 8 hours of the study. The antibacterial action of the lipo- somal formulation was compared to that of the pure drug solution and it was found that the liposomal formulations loaded with Azithromycin were able to exhibit comparable antibacterial activity against Staphylococcus aureus in the disc diffusion assay, as measured using the zone of inhibi- tion.

Articles Details

NAMES:

ONLINE ISSN:2456-8244

Keywords: Azithromycin, liposomes, reverse phase evaporation, antibacterial, release

DOI:

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