JOURNAL OF PHARMACOLOGY AND
BIOMEDICINE
ISSN.2456-8244
In the present work newer antioxidants based on qui- nalzoline nucleus were synthesized and evaluated. The confirma- tion of the structure of the synthesized compounds was done by IR, 1HNMR and mass spectral studies. The antioxidant potential of the synthesized compounds was also evaluated and the the data reveals IC50 value of 17.4 to 32.6 µg/mL against DPPH radical and 18.3 to 37.4 µg/mL against hydroxy radical. The compounds 4d & 4e exhibited the best antioxidant activity against DPPH and HRSA assays. The results revealed that higher electron withdrawing po- tential in the benzene substituent resulted in higher antioxidant capacity. On the other hand compound 4a with an aliphatic chain exhibited the least antioxidant activity in both the assays.
NAMES:
ONLINE ISSN:2456-8244
Keywords: Quinazoline , microwave , antioxidant , DPPH , HRSA
DOI:
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