Matrix tablets of Ciprofloxacin were prepared using guar gum as the matrix forming polymer and incorporating Sporlac and Vivaflora probiotics in varying quantity to assist the targeted release of the drug in the colonic microflora. The angle of repose was found to be in the range of 26°32’ to 28°52’. The bulk density value ranged from 0.360 to 0.45 g/cm3 while the tapped density value ranged from 0.50 to 0.54 g/cm3. The granules prepared in the present work were found to have the Carr’s Index between 15.68 to 18.51 % and the Hausner’s ratio was found to be ranging from 1.186 to 1.227. The thickness of all the tablets was found to be 6 mm while the hardness ranged from 5.2-5.3 kg/cm2. The friability and weight variation were found to be less than 0.3% and the drug content in each tablet was found to be 98 - 99%. The matrix tablets were also investigated for the in vitro drug release in absence and presence of rat caecal content and it was found that the release of drug from the tablets was affected by the presence of probiotics. The rat caecal content was able to increase the drug release from all the formulation. The drug release was highest from the formulation MT4 which exhibited 98.78% and 99.84 %cumulative release in absence and presence of rat caecal content respectively.

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ONLINE ISSN:2456-8244

Keywords: Ciprofloxacin, probiotic, colon, microflora, matrix tablet, release

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REFERENCES

 

1. Ahmed IS, Ayres JW (2011). Comparison of in vitro and in vivo performance of a colonic delivery system. International Journal of Pharmaceutics, 409 (1-2), 169-177
2. Ahuja V, Tandon RK (2010). Inflammatory bowel disease in the Asia–Pacific area: A comparison with developed countries and regional differences. Journal of Digestive Diseases, 11, 134-147
3. Ghosh PK, Gupta VB, Gondoliya B, Rathore MS. (2010). Probiotic-assisted colon-specific delivery of diclofenac sodium from guar gum matrix tablets: In vitro evaluation. Asian Journal of Pharmaceutics, 4(4): 173-178
4. Goindi S, Mann K, Aggarwal N (2011). Gastro-retentive floating beads of curcumin β-cyclodextrin complex to treat stomach tumors. Alternative Medicine Studies, 1 (e12), 49-53
5. Libo Y, Chu JS, Fix JA (2002). Colon-speci?c drug delivery: new approaches and in vitro/in vivo evaluation. International Journal of Pharmaceutics, 235, 1-15
6. Radhika PR, Pal TK, Sivakumar T (2009). Formulation and evaluation of sustained release matrix tablets of glipizide. Iranian Journal of Pharmaceutical Sciences, 5(4), 205-214
7. Tomlin J, Read NW, Edwards CA, Duerden BI (1986). The degradation of guar gum by a faecal incubation system. British Journal of Nutrition, 55, 481-486.
8. Jalonya R, Soni P, Malviya K, Omray LK (2018). Formulation and evaluation of bilayer tablets of diltiazem HCl. Journal of Pharmacology and Biomedicine, 2(3), 189-198