JOURNAL OF PHARMACOLOGY AND
BIOMEDICINE
ISSN.2456-8244
Triazines are a widely studied class of compounds having various pharmacological activities. In this work, Mannich bases of 1,2,4-triaizine were synthesized and evaluated for antibacterial action. The synthesis was achieved in two simple steps involving formation of traizine nucleus and subsequent Mannich base for- matiom. The compound TZM5 & TZM6 showed the highest antimi- crobial activities against all of the tested organisms (bacteria). In contrast, compound TZM1 showed lower antimicrobial activity against all tested microorganisms.
NAMES:
ONLINE ISSN:2456-8244
Keywords: 1,2,4-triazine, Antibacterial, Mannich base, prodrug, Zone of inhibition
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