Journal Logo
JOURNAL OF PHARMACOLOGY AND BIOMEDICINE
ISSN.2456-8244
Editor-in-Chief
Dr.Richa Mishra Online ISSN
2456-8244 Publisher
RB-Science Abbreviation
J. Pharmacol. Biomed
ABSTRACT

The aim of the present study was to evaluate essential oils as penetration enhancers for transdermal gels using Ibuprofen as a model drug. Ibuprofen was formulated as a 5% carbopol gel. The amount of co-solvent (ethanol and propylene glycol) was optimized so as to obtain a homogenous gel. The prepared gels were evaluated for pH, spreading and homogeneity. Gel containing 5% drug, 0:15 proportion of ethanol: water and 1.5% carbopol was selected as base gel. The penetration of the gel was studied through cellulose membrane, egg shell membrane and rat skin. The gels containing different penetration enhancers were compared using various parameters like transdermal flux, permeability coefficient, and enhancement ratio and lag time. Anise oil was selected as the optimized essential oil for the gel formulations. The gel prepared using anise oil was studied for drug release kinetics and occlusivity. The gel was further studied for skin irritation in rat i.e. the formation of erythema and edema and compared with placebo gel and marketed formulation. The anise oil containing gel can be used to deliver therapeutically relevant doses of ibuprofen-like drugs.

Articles Details

NAMES:

ONLINE ISSN:2456-8244

Keywords: Essential oil, penetration enhancer, transdermal, gel, ibuprofen, ex vivo

DOI:

REFERENCES
  1. Abdul Rasool BK, Abu-Gharbieh EF, Fahmy SA, Saad HS, Khan SA (2010) Development and Evaluation of Ibuprofen Transdermal Gel Formulations. Trop J Pharm Res 9(4): 355-363
  2. Chandrashekhar NS, Shobha R (2008) Physicochemical and pharmacokinetic parameters in drug selection and loading for transdermal drug delivery. Indian J Pharm Sci 70: 94-95
  3. Gupta A, Mehta P, Jain A (2021) Formulation and evaluation of transdermal patches of Lamotrigine. J Pharmacol Biomed 5(1): 242-248
  4. Herman, Anna, and Andrzej P. Herman (2015) Essential oils and their constituents as skin penetration enhancer for transdermal drug delivery: a review. J Pharm Pharmacol 67(4): 473-485
  5. Kashyap A, Das A, Ahmad AB (2020) Formulation and Evaluation of Transdermal Topical Gel of Ibuprofen. J Drug Del Ther 10(2): 20-25
  6. Kushwaha R, Malviya K, Omray LK (2018) Formulation development of herbal anti acne gel. J Pharmacol Biomed 2(4): 199-210
  7. Singh AP, Mishra B (2020) Evaluation of anti-inflammatory potential of Rutin using in vitro models. J Pharmacol Biomed 4(1): 211-217

Syed SM, Gaikwad SS, Wagh S (2020) Formulation and evaluation of gel containing fluconazole microsponges. Asian J Pharm Res Dev 8(4): 231-239