The objective of the current investigation was to formulate matrix tablets of norfloxacin that could control the release of the drug thereby reducing its dosing frequency and improving the bioavailability. The objective was accomplished by preparation of the matrix tablets using HPMC and xanthan gum as the matrix forming polymers. The angle of repose for all formulations was found to be within the range from 24°22 to 26°18. The bulk density and tapped density values were found to be within the range from 0.42 to 0.58 and 0.53 to 0.67 respectively. The Hausner’s ratio values were found to be within the range from 1.06 to 1.21.The thickness of all formulation was ranged in between 4.1 to 4.3 mm while the hardness of the formulations ranged from 4.1 to 4.6 Kg/cm2. The friability of all formulation was in the range of 0.23% to 0.61% and the weight variation was in the range of 0.48 to 0.56 %. Swelling study was performed on all the formulation for 9 h. The results of swelling index were shown in table. All formulation was in the range of 1.37 to 5.31. The highest degree of swelling was achieved by F9 that contained highest concentration of HPMC and xanthan gum. The formulation F7-F9 were able to release almost 100% of the drug at the end of 12 h duration.

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ONLINE ISSN:2456-8244

Keywords: Norfloxacin, controlled release, matrix tablet, xanthan gum, HPMC, precompression

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