JOURNAL OF PHARMACOLOGY AND
BIOMEDICINE
ISSN.2456-8244
Etodolac transdermal patches formulated with PEG-400 as plasticizer and polymers HPMC and ethyl cellulose by solvent cast- ing method are quite stable, there is no interaction between drug and formulation component on the basis of physical appearance and FTIR data. The average weight of the patches (2.54 cm2) was found to be ranging from 158 to 165 mg. The thickness of the patches ranged from 0.245 to 0.346 mm and was found to be de- pendent on the polymer ratio. The patches were able to withstand 43 to 78 folds at same place in the folding endurance test. All the formulations were able to incorporated uniform quantity of drug in them ranging from 98.5 to 99.2 %. The results of moisture content study revealed that increase in concentration of HPMC was direct- ly proportional to the moisture content in the patches with F6 ex- hibiting the highest moisture (7.25%) while F1 exhibiting the low- est (5.11%). The drug was released ranging from 88.3 to 60.7 % in various formulations. The regression coefficients of the graphical representation of the mathematical models reveal that the release of etodolac from the patches can be described by Korsemeyer- Peppas model. The expression relates that the drug released from the patches is due to diffusion of drug from the polymeric matrix of the patch and is primarily diffusion controlled.
NAMES:
ONLINE ISSN:2456-8244
Keywords: Etodolac Transdermal patch Sustained Release HPMC Ethyl Cellulose
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