JOURNAL OF PHARMACOLOGY AND
BIOMEDICINE
ISSN.2456-8244
The valorization of agricultural waste into functional nanomaterials represents a sustainable approach to nanotechnology. In this study, coconut husk ash extract was utilized as a green precursor for the synthesis of mesoporous silica nanoparticles (MSNs) via a sol-gel method using cetyltrimethylammonium bromide (CTAB) as a structure-directing agent. The nanoparticles were characterized for particle size, polydispersity index (PDI), zeta potential, surface morphology, and FTIR spectra. Results indicated particle sizes ranging from 247 to 722 nm with PDIs between 0.118 and 0.168, confirming acceptable homogeneity. Zeta potential values ranged from -18.9 to -22.2 mV, consistent with silanol group deprotonation. SEM analysis revealed spherical morphology with smooth surfaces, validating successful condensation and template removal. Antioxidant activity was evaluated using the DPPH radical scavenging assay, with the optimized formulation (SP4) showing dose-dependent inhibition and an IC₅₀ value of 33.18 µg/mL. These findings highlight the potential of coconut husk ash-derived MSNs as eco-friendly nanocarriers with significant antioxidant activity, offering promise for biomedical and nutraceutical applications.
NAMES:
ONLINE ISSN:24568244
Keywords: Coconut husk ash; Green synthesis; Mesoporous silica nanoparticles; Antioxidant activity; DPPH assay
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