JOURNAL OF PHARMACOLOGY AND
BIOMEDICINE
ISSN.2456-8244
Naringenin, a naturally occurring flavanone predominantly found in citrus fruits, exhibits diverse pharmacological activities including antioxidant, anti-inflammatory, anticancer, cardioprotective, and neuroprotective effects. Despite these promising biological properties, the clinical translation of naringenin is severely limited by its poor aqueous solubility, extensive first-pass metabolism, low intestinal permeability, and rapid systemic elimination, resulting in low oral bioavailability. Nanoformulation-based drug delivery systems have emerged as effective strategies to overcome these limitations by enhancing solubility, protecting the drug from degradation, improving absorption, and enabling controlled or targeted delivery. This review comprehensively discusses various nano-enabled delivery platforms developed for naringenin, including polymeric nanoparticles, lipid-based carriers, nanoemulsions, nanosuspensions, phytosomes, and hybrid systems. Mechanistic insights into bioavailability enhancement, pharmacokinetic improvements, and therapeutic implications are critically analysed. The review highlights current challenges and future prospects for translating naringenin nanoformulations into clinical applications.
NAMES:
ONLINE ISSN:2456-8244
Keywords: Naringenin, Nanoformulation, Bioavailability, Nanoparticles, Lipid-based delivery, Phytosomes
DOI:
Bhandari, P., et al. (2023) Enhanced bioavailability and brain targeting of naringenin via coated PLGA
nanoparticles, PubMed. (PubMed)
Bhandari, P., Kumar, V., Sharma, R. and Jain, A. (2023) Enhanced bioavailability and brain
targeting of naringenin via PLGA nanoparticles. International Journal of Pharmaceutics, 622, Article ID
121873.
Bhia, M., Motallebi, M., Abadi, B., Zarepour, A., Pereira-Silva, M., Saremnejad, F., Santos, A.C.,
Zarrabi, A., Melero, A., Jafari, S.M., et al. (2021) Naringenin nano-delivery systems and their therapeutic
applications, Pharmaceutics, 13(2), 291. (MDPI)
Bhia, M., Motallebi, M., Abadi, B., Zarepour, A., Pereira-Silva, M., Saremnejad, F., Santos, A.C.,
Zarrabi, A., Melero, A. and Jafari, S.M. (2021) Naringenin nano-delivery systems and therapeutic
applications. Pharmaceutics, 13(2), Article ID 291.
Cheng, Y., Luo, L., Wang, Y. and Li, J. (2021) Chitosan-coated polymeric nanoparticles of
naringenin for oral delivery. Carbohydrate Polymers, 262, Article ID 117940.
Djebbar, R., Bensouici, C., Benkhaled, A. and Hadjadj, M. (2024) Comparative bioavailability of
naringenin nano-carriers. Journal of Drug Delivery and Therapeutics, 14(10), pp. 129–136.
Djebbar, R., et al. (2024) Comparative analysis of naringenin nano-carriers PLA/PVA and zein/pectin for
bioavailability, Journal of Drug Delivery & Therapeutics, 14(10), 129-136. (Drug Delivery Journal)
Gupta, S., Mishra, A. and Singh, P. (2020) Phytosome-based delivery of naringenin. Journal of Herbal
Medicine, 24, Article ID 100392.
Huang, Y., Zhang, Y., Chen, X. and Li, Z. (2020) Liposomal naringenin for anticancer therapy.
Drug Delivery, 27(1), pp. 173–183.
International Journal of Applied Pharmaceutics (2025) SNEDDS of naringenin: formulation and
pharmacokinetics. International Journal of Applied Pharmaceutics, 17(1), pp. 45–53.
Khan, R. and Jain, A. (2025) Nanostructured lipid carriers of naringenin. Colloids and Surfaces B:
Biointerfaces, 234, Article ID 113045.
Khan, S., Ahmad, M. and Rizvi, S.M.D. (2022) PLGA nanoparticles for sustained delivery of
naringenin. European Journal of Pharmaceutical Sciences, 168, Article ID 106044.
Kumar, A., Sharma, S. and Verma, R. (2019) Solid lipid nanoparticles of naringenin. Drug
Development and Industrial Pharmacy, 45(7), pp. 1135–1144.
Li, J., Wang, X. and Zhang, T. (2019) Gelatin nanoparticles for oral delivery of flavonoids. AAPS
PharmSciTech, 20, Article ID 187.
Liang, J., Yan, H., Zhang, J. and Wang, Y. (2016) Liposomal formulation improves oral
bioavailability of naringenin. Journal of Analytical Science and Technology, 7, Article ID 12.
Luo, Y., Teng, Z., Wang, Q. and Zhang, Y. (2021) Zein-based nanoparticles for naringenin
delivery. Food Chemistry, 345, Article ID 128800.
Modi, P., Choudhury, P.K. and Sharma, M. (2025) Phytosome based drug delivery of naringenin and
naringin: development, characterization, in vivo evaluation, Asian Journal of Pharmaceutical Research &
Development. (Ajprd)
Patel, R., Patel, M. and Bhatt, D. (2020) Oral solid lipid nanoparticles of naringenin. Journal of
Pharmaceutical Sciences, 109(6), pp. 1891–1899.
Rajamani, S. (2019) Pharmacokinetic and tissue distributions of naringenin and naringenin nanosuspension,
Asian Journal of Pharmaceutics. (Asian Journal of Pharmaceutics)
Rajamani, S. (2019) Pharmacokinetics of naringenin nanosuspension. Asian Journal of Pharmaceutics,
13(4), pp. 311–318.