JOURNAL OF PHARMACOLOGY AND
BIOMEDICINE
ISSN.2456-8244
Sesame (Sesamum indicum L.) is a traditional oilseed crop widely recognized for its nutritional and medicinal importance. While extensive research has focused on sesame seeds and oil, sesame leaves have recently gained attention due to their rich phytochemical composition, including flavonoids, phenolic acids, alkaloids, and glycosides, which exhibit antioxidant, anti-inflammatory, antimicrobial and cytoprotective properties. However, the therapeutic exploitation of sesame leaf extract is limited by poor aqueous solubility, chemical instability, rapid metabolism and low bioavailability. Nanotechnology-based delivery systems have emerged as promising strategies to overcome these challenges. This review critically examines the phytochemical profile of sesame leaves, discusses recent advances in nanoformulation approaches—including green-synthesised nanoparticles, exosome-like nanovesicles, nanoemulsions and polymeric nanocarriers—and highlights their physicochemical characteristics and biomedical applications. Key challenges related to standardization, safety and regulatory translation are also addressed, followed by future prospects for clinical and industrial applications.
NAMES:
ONLINE ISSN:2456-8244
Keywords: Sesame, nanoformulation, phytochemicals, antioxidant, cytoprotective
DOI:
https://www.drugbank.ca/drugs/DB00936 assessed on 27/01/2026.
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