JOURNAL OF PHARMACOLOGY AND
BIOMEDICINE
ISSN.2456-8244
Griseofulvin, a well-established antifungal agent, has traditionally been administered orally for the treatment of dermatophytic infections. However, its poor water solubility, limited bioavailability, and systemic side effects have prompted the exploration of topical delivery systems to enhance localized efficacy and minimize adverse effects. This review consolidates recent advancements in topical formulations of griseofulvin, including liposomes, invasomes, nanogels, and polymeric films. These novel carriers improve drug permeation, retention, and therapeutic outcomes. The article critically evaluates formulation strategies, physicochemical characteristics, and in vitro/in vivo performance, highlighting the potential of nanotechnology-driven systems in revolutionizing antifungal therapy.
NAMES:
ONLINE ISSN:2456-8244
Keywords: Griseofulvin, topical delivery, nanogel, liposomes, invasomes, bioavailability enhancement
DOI:
Anonymous. (2023). Formulation and evaluation of griseofulvin-loaded invasomal gel for
efficient topical delivery to treat dermatophytosis. International Journal of Pharmaceutical Sciences.
https://www.ijpsjournal.com/article/Formulation+And+Evaluation+of+GriseofulvinLoad
ed+Invasomal+Gel+for+Efficient+Topical+Delivery+to+Treat+Dermatophytosis
Bangar, P., Gupta, R., Gupta, N. B., Sharma, P., Kaur, H., Singh, S., Thakur, R., & Kumar, S.
(2023). Formulation and evaluation of topical nanogel containing griseofulvin for the
treatment of fungal infection. YMER Digital.
https://ymerdigital.com/uploads/YMER231108.pdf
Barry, B. W. (2001). Novel mechanisms and devices to enable successful transdermal drug
delivery. European Journal of Pharmaceutical Sciences, 14(2), 101–114.
https://doi.org/10.1016/S0928-0987(01)00167-1
Cevc, G., & Blume, G. (2001). New, highly efficient formulation of diclofenac for the topical,
transdermal administration in inflammatory disorders. Biochimica et Biophysica Acta (BBA) -
Biomembranes, 1514(2), 191–205. https://doi.org/10.1016/S0005-2736(01)00395-5
El Maghraby, G. M., Barry, B. W., & Williams, A. C. (2008). Liposomes and skin: From drug
delivery to model membranes. European Journal of Pharmaceutical Sciences, 34(4–5), 203–222.
https://doi.org/10.1016/j.ejps.2008.05.002
Honeywell-Nguyen, P. L., & Bouwstra, J. A. (2005). Vesicles as a tool for transdermal and
dermal delivery. Drug Discovery Today: Technologies, 2(1), 67–74.
https://doi.org/10.1016/j.ddtec.2005.05.002
Jain, S., Tiwary, A. K., & Jain, N. K. (2006). Permeation enhancement by niosomes and
ethosomes through human cadaver skin. Drug Development and Industrial Pharmacy, 32(4), 393–
403. https://doi.org/10.1080/03639040500512813
Jain, S., Tiwary, A. K., Sapra, B., & Jain, N. K. (2007). Formulation and evaluation of
ethosomes for transdermal delivery of lamivudine. AAPS PharmSciTech, 8(4), 111.
https://doi.org/10.1208/pt0804111
Mishra, P. K., Mishra, K., & Mehta, P. (2023). Formulation and characterization of griseofulvin
liposome-loaded topical film. International Journal of Fundamental and Multidisciplinary Research.
https://www.ijfmr.com/papers/2023/5/6152.pdf
Nair, R., & Kumar, A. (2013). Nanogel as a novel drug delivery system. International Journal of
Pharmacy and Pharmaceutical Sciences, 5(3), 1–5.
Prausnitz, M. R., & Langer, R. (2008). Transdermal drug delivery. Nature Biotechnology, 26(11),
1261–1268. https://doi.org/10.1038/nbt.1504
Prow, T. W., Grice, J. E., Lin, L. L., Faye, R., Butler, M., Becker, W., ... & Roberts, M. S. (2011).
Nanoparticles and microparticles for skin drug delivery. Advanced Drug Delivery Reviews, 63(6),
470–491. https://doi.org/10.1016/j.addr.2011.01.012
Raza, K., Singh, B., & Lohan, S. (2014). Topical delivery of aceclofenac: Challenges and
promises of novel drug delivery systems. Biomed Research International, 2014, 406731.
https://doi.org/10.1155/2014/406731.
Sahu, P. K., & Das, M. K. (2014). Formulation and evaluation of chitosan-based griseofulvin
gel for topical delivery. Indian Journal of Pharmaceutical Education and Research, 48(1), 41–46.
Verma, D. D., Fahr, A. (2004). Synergistic penetration effect of ethanol and phospholipids on
the topical delivery of cyclosporin A. Journal of Controlled Release, 97(1), 55–66.
https://doi.org/10.1016/j.jconrel.2004.03.013